Dual-sample Ultra Imaging System setup capturing block-face images from two tissue samples for high-throughput volumetric imaging.

Optical HREM ULTRA

Optical High-Resolution Episcopic Microscopy ULTRA System for Complex 3D Imaging

Imaging of Larger Volumes in 3D at Higher Resolution with Ultra

Optical HREM Ultra is a flexible 3D imaging system built for generating detailed volume data. It’s designed to handle a wide range of HREM applications, from fast high-throughput scans to high-resolution imaging in dense or complex samples.

Ultra lets you image based on the resolution you need, not the size of your sample, achieving sub-micron lateral resolution while still accommodating larger specimens up to 30 mm or more.

It’s well-suited for imaging complex tissue structures, whole organs, embryonic development, and for labs developing or adapting HREM techniques.

Optical HREM Ultra 3D Imaging system for scanning images

Key Advantages of the Ultra System

3D Morphology Without Artifacts

HREM captures images from a freshly cut block face, without advanced handling of the data, eliminating warping, tearing and misalignment. It is highly repeatable and accurate preserving spatial relationships between structures.

Fully Aligned Data for Structural 3D Analysis

Ultra outputs perfectly aligned stacks, without the need for registrations. Ideal for volume rendering, segmentation and quantification, reducing man hours dramatically.

Uniform Resolution Through Dense Volumes

HREM offers consistent lateral and axial resolution throughout an entire sample, with the ultra-providing higher resolution capabilities. Not only higher resolution but without optical distortion.

Scalable and Reproducible 3D Imaging

Once at home with HREM the automated sectioning and imaging allows for a reproducible workflow, suitable for single sample studies or large experimental series.

Large Sample Capabilities at High Resolution

Ultra allows for imaging of larger samples with enhanced sectioning platform and scanning allowing for up to 60mm of scanning area. Suitable for whole embryos, entire organs or larger tissue blocks.

Experimentation and Method Development

Open and customizable imaging for development of new protocols for fluorescence on a wide range of samples and stains. As well as support use of new and exciting samples that expand HREMs sample range, that may be incompatible with other techniques.

Mouse embryo morphology, block face imaged showing cellular detail in 3D

Ultra Summary

Ultra systems allow for increased resolution using scanning, to adapt the magnification to the desired value and not the size of the sample. Allowing for 0.5 micron lateral resolution across denser, larger samples.
Image up to 60mm area, dependent on sample, with near histology detail. Ideal for developmental biology, organogenesis and pathology
Batch imaging of up to 4 blocks (more samples), increases throughout and decreases user interaction.
Add optional fluorescence setups to perform MF-HREM imaging with faster detectors for experimental research.