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HREM Embryonic Mouse Brain 2D Section Imaged for 3D Morphology

Whole Organ Imaging With HREM

Optical High-Resolution Episcopic Microscopy for Whole Organ Imaging

HREM Brain Organ

Whole Organ Architecture in 3D

Whole organ imaging in rodents and other species is a powerful tool in many areas such as developmental biology, pathology and phenotyping. With traditional histology techniques images can only be analysed in the 2D domain as well as contain artefacts that may displace the ability to quantify the sample.

HREM overcomes the issue of aligning whole organ imaging by capturing the block face, while keeping tissue integrity, producing a stack of perfectly aligned 2D images for 3D reconstruction. Applications of HREM include brain, kidney, liver, heart etc.

Why use HREM for Whole Organ Imaging

Structural Accuracy

Structural integrity of you’re sample remains in tact and consistent throughout imaging allowing both 2D and 3D analysis. Useful for developmental biology, disease models and anatomical atlases

Full Organ Coverage in 3D

Produce 3D models of dense tissue over entire mouse organs at resolutions ranging from 1-8 microns, from 1-20mm in sample size.

Quantitate & Reproducible

Imaging is consistent across samples allowing for for easy comparison and quantitate studies.

No Clearing or Interpolation

HREM image stacks are very simple and clear, little processing is done by us to you (well none really), meaning you are seeing raw data. No interpolation is required for resolutions of 1-8 micron voxel sizes.

Applications for HREM in Whole Organ Imaging

Kidney Morphology

Allows visualisation of kidney shape and structure for volume measurements, structural comparisons etc. Supports toxicology and developmental nephrology with reproducible imaging.

Cardiac Imaging

3D cardiac structures ideal for neonatal hearts for developmental abnormalities.

Tumour and Lesion Reconstruction

Capture abnormal structures and growths across entire organs including lesions and tumours. HREM provides precise localisation, volume quantification and further analysis.

More

More

  • Brain development

  • Lung architecture

  • Reproductive studies 

Contact our High-Resolution Episcopic Microscopy (HREM) Experts

Request a quote or a meeting to discuss the Optical HREM Micro instrument using the form.

Contact Us 

Intech House

34-35 Wilbury Way

SG4 0TW

Hitchin

Hertfordshire 

United Kingdom

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© 2025 by Indigo Scientific.

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