Capture Embryonic Development in 3D
From organogenesis to subtle phenotype detection HREM systems support the most demanding of developmental studies.
3D Imaging of Dense Whole Tissue & Bone at Micron Resolution
Developmental biology, including imaging of Mouse embryos for the study of embryonic development, requires capture of dense bone or tissue that can be hard to visualise in 3D with conventional techniques. HREM provides a solution of imaging denser volumes with precision in the 3D domain, unlike traditional histology where sections can be distorted, misaligned and obscure finer features that restrict use in the spatial domain.
High-Resolution Episcopic Microscopy (HREM) provides full 3D, distortion free imaging at micron-level resolution, making it ideal for developmental studies in model organisms.
Benefits to HREM in Developmental Biology
Whole Embryo Imaging
Produce complete 3D volumes, comprised of 2D stacks of chick, mouse or fly embryos.
Phenotype Detection
Analyse subtle anatomical changes in gene knockouts and mutants.
Micron Scale Resolution
Resolve fine structures such as blood vessels across entire structures and specimens with 1–8-micron voxel sizes.
High Contrast Imaging
Consistent image contrast across entire volumes using block-face fluorescence.
Accurate Morphometrics
Measure internal and external volumes, surface areas and spatial relationships easily with defined contrast.
Potential Applications within Developmental Biology
Mouse & Chick Embryo Analysis
Study normal developmental stages in mice and chick embryos as well as detect congenital abnormalities or gene mutation effects.
Zebrafish & Drosophila Models
HREM Provides an easy platform for imaging vascular development in small, translucent embryos.
Cardiac Morphogenesis
Study heart looping, septation and early valve formation in mouse embryos.
Contact our High-Resolution Episcopic Microscopy (HREM) Experts
Request a quote or a meeting to discuss the Optical HREM Micro instrument using the form.
Phone: +44(0) 1462633500