Block-face HREM imaging of embryonic cardiovascular system

3D Imaging of Cardiovascular Development

Visualise heart chambers, valves, and vessels in full 3D using high-resolution block-face microscopy.

3D reconstruction of mouse embryonic heart using HREM showing ventricles and atria

Imaging for Embryonic Heart and Vessel Morphology in 3D

HREM provides the option to visualise embryonic hearts and blood vessels at early stage in high resolution with clear 3D contrast, without sample clearing.

Whether you're studying congenital heart defects, vascular remodelling, or embryonic cardiac morphogenesis, HREM provides the resolution and accuracy needed for reliable insight.

Full High Resolution 3D Image Stacks of Heart Samples

Optical HREM systems provide a platform for imaging denser samples at resolutions that help identify subtle morphological differences.

Datasets are comprised of 2D image sections, producing 3D model with no axial shift can be created from the raw images producing voxel sizes of 1-8 microns over the whole sample.

Why Choose HREM for Cardiac and Vascular Imaging

Whole Heart 3D Imaging

Capture entire embryonic or neonatal hearts at high resolution without distortion.

Morphological Defect Detection

Detect separation defects valve anomalies and abnormal chamber formation.

Detailed Vasculature Imaging

Image coronary cranial and systemic vessels down to fine branches.

Quantitative Analysis

Achieve accurate 3D models for volume, thickness and more.

High-Contrast Soft Tissue Imaging

Consistent and excellent contrast and clarity across myocardium, valves and vessels.

No Clearing

HREM does not rely on clearing for image clarity, improving contrast and repeatability.

High-resolution 3D image of late-stage mouse heart showing mature chambers and vascular structures

Applications for HREM in Cardiovascular Research

High-Resolution Episcopic Microscopy is a useful imaging tool in 3D cardiac imaging of thicker samples usually around 1mm+. These samples can include mice, zebrafish, fish and more. HREM is suited to samples sub 20mm in size.